Sometimes things are just… psychically wrong. There might be things make you wince and feel a touch squeamish. In short, some content may be disturbing to some players. Some things should be disturbing to players to create atmosphere and connection with the game world.
When I mention "disturbing content" it is meant in a Lovecraftian sense, but it could also be in a "Saw" or face-of-evil, gratuitous gore or violence sense, too. In general, graphic sex and sexual violence are completely off the table (I'm not really talking about boobies; who doesn't like boobies?), but other societal taboos are not:
These are common themes in the source materials that fantasy games draw on, and it's not unheard of that enemies and villains1) may partake in them. I can't see elaborating on any of that in graphic detail or in a way that triggers someone, but if the very idea of it existing or merely mentioning it during play is hard for you then we might occasionally cross a line for you.
I guess what I'm trying to say is that my games can potentially be rated M for mature for violence, disturbing scenes and language, but it's not guaranteed.
(On the plus(?) side, if I am making the game more squeamish, it means I'm more comfortable with the folks around the table.)